Cell Division Protein Kinase 2



Cell Division Protein Kinase 2 or cyclin-dependent kinase 2 (CDK2) is involved in the control of the cell cycle. It interacts with the regulatory protein cyclin. Phosphorylation at Thr14 or Tyr15 inactivates it; phosphorylation at Thr160 (T160P) – activates it. The images on the left and right correspond to one representative CDK2 structure, i.e. the human Cell Division Protein Kinase 2 (1pw2).

3D Structures of Cell Division Protein Kinase 2
Update June 2011

1pw2, 1hck, 1hcl – hCDK2 – human

1b39 - hCDK2 T160P

3ns9, 3le6, 2xmy, 2xnb, 3lfn, 3lfq, 3lfs, 3ig7, 3igg, 3fz1, 3ezr, 3ezv, 2w1h, 2w17, 2w05, 2w06, 2r64, 2vta, 2vth, 2vti, 2vtj, 2vtl, 2vtm, 2vtn, 2vto, 2vtp, 2vtq, 2vtr, 2vts, 2vtt, 2vu3, 2vv9, 2r3f, 2r3g, 2r3h, 2r3i, 2r3j, 2r3k, 2r3l, 2r3m, 2r3n, 2r3o, 2r3p, 2r3q, 2r3r, 2j9m, 2v0d, 2duv, 2clx, 2fvd, 2a4l, 1w8c, 2a0c, 2exm, 2bpm, 2c68, 2c69, 2c6i, 2c6k, 2c6l, 2c6m, 2c6o, 2c6t, 2btr, 2bts, 2b52, 2b53, 2b54, 2b55, 2bhe, 2bhh, 1y8y, 1y91, 1wcc, 1w0x, 1pye, 1vyz, 1vyw, 1v1k, 1urw, 1pxm, 1pxn, 1pxo, 1pxp, 1r78, 1pf8, 1pxi, 1pxj, 1pxk, 1pxl, 1oiq, 1oir, 1oit, 1p2a, 1h00, 1h01, 1h07, 1h08, 1h0v, 1h0w, 1gz8, 1ke5, 1ke6, 1ke7, 1ke8, 1ke9, 1gih, 1gii, 1gij, 1jvp, 1g5s, 1jsv, 1e1v, 1e1x, 1fvt, 1fvv, 1di8, 1dm2, 1ckp, 1aq1, 3pxf, 3pxq, 3pxr, 3pxy, 3pxz, 3py0, 3py1, 3pj8 – hCDK2 + inhibitor

2ds1 – hCDK2 (mutant) + inhibitor

1fq1 - hCDK2 +cyclin-dependent kinase inhibitor 3

1buh – hCDK2+ protein CKSHS1

1ua2 – hCDK7

CDK2+cyclin
3my5 – hCDK2 + cyclin A2

2jgz - hCDK2 T160P + cyclin B1

1w98 - hCDK2 + cyclin E1

2wma, 2wmb, 2x1n, 2wev, 2wfy, 2whb, 2v22, 2cch, 1okv, 1okw, 1ol1, 1ol2, 1urc, 1h24, 1h25, 1h26, 1h27, 1h28, 1gy3, 3qhr, 3qhw - hCDK2 + cyclin A2+peptide ligand

2wpa, 2wxv, 2wih, 2wip, 3f5x, 3eoc, 3eid, 3ej1, 2uzb, 2uzd, 2uze, 2uzl, 2uzn, 2uzo, 2uue, 2i40, 2bkz, 2c5n, 2c5o, 2c5v, 2c5x, 2c5y, 1ykr, 2c4g, 1p5e, 1pkd, 1fin – hCDK2 + cyclin A2 + inhibitor

3ddp, 3dog, 3ddq, 3bht, 3bhu, 3bhv, 2iw6, 2iw8, 2iw9, 2g9x, 2cjm, 1oi9, 1oiu, 1oiy, 1ogu, 1h1p, 1jst - hCDK2 T160P+ cyclin A2 + inhibitor

2cci, 1qmz - hCDK2 T160P + cyclin A2+peptide ligand

1h1p, 1h1q, 1h1r, 1h1s, 1e9h - hCDK2 T160P + cyclin A3 + inhibitor

1jsu - hCDK2 + cyclin A2+ protein P27